Lyon welcome back two long-term injury victims, with Clement Grenier available having not played since August due to a groin injury and Gueida Fofana (ankle) rejoining the squad for the first time since March, while Christophe Jallet and Yoann Gourcuff remain sidelined and Lindsay Rose is suspended.
Forward Yassine Benzia earned a rare appearance as a substitute during their 3-1 win over Guingamp last time out and is determined to put pressure on the club's in-form strike pair Alexandre Lacazette and Nabil Fekir.
Lyon scored at least one goal in 93% of their home games and at least one goal in each of their last thirteen home games.
The guests saw their dreams of lifting their first major trophy in over 30 years crushed by a solid PSG outfit at the weekend, having played with 10 men for 70 minutes following Sébastien Squillaci's questionable red card. Ghislain Printant's men are currently on a 3-game losing run, sitting only 2 points above the relegation zone, and they may find it very difficult to recover in time from the weekend's disappointment against a motivated Lyon side, who appear to be both physically and mentally well-prepared to return to the top of the league on Wednesday.
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