Southampton - Manchester United

This time last year, Koeman, in his first season on the South Coast, lifted Southampton up to second in the table with 10 points from a possible 15. Fast forward 12 months and the Dutchman's side now sit 11th with six points. Having flirted with Champions League qualification for so long last time around, second-season syndrome was a perceived risk for them and, in truth, that risk is becoming more real every week. It is not beyond the realms of possibility that third-placed Manchester United will be eight points behind City by the time their clash with Southampton gets underway on Sunday. Only a win will do for Van Gaal and co. Having successfully returned to the Champions League, a title challenge is now a must for the Red Devils, but if their early-season results are anything to go by then inconsistency may undermine them for the second campaign in succession. Van Gaal's men were solid if unspectacular in their opening two games, with Kyle Walker's own goal enough to give them a 1-0 win over Tottenham Hotspur at Old Trafford in the Premier League curtain-raiser, before Adnan Januzaj's deflected effort downed Villa by the same scoreline six days later. Pick away win.